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Pharmacological effect

Many gram-positive and gram-negative bacteria are sensitive to the action of Augmentin, among which:

 

  • E. coli, including those producing beta-lactamase;
  • enterobacteria;
  • Klebsiella;
  • Staphylococcus aureus, including beta-lactamase producing strains;
  • streptococcus;
  • Neisseria, the causative agent of gonorrhea;
  • moraxella;
  • Proteus.

 

Separately, we note that methicillin-resistant strains of Staphylococcus aureus, which cause dangerous nosocomial infections, are insensitive to Augmentin https://augmentin875mg.net/.

The mechanism of action of Amoxicillin is extremely simple. The antibiotic blocks the synthesis of the cell wall of a sensitive microorganism and thus has a bactericidal effect.  The pharmacological effect in Augmentin has only one active substance of the drug - amoxicillin. Clavulanic acid has no antibacterial effect.

The composition of the drug Amoxicillin + Clavulanic acid-Vial

Composition per tablet:

Dosage 250 + 125 mg

Active ingredients: amoxicillin - 250 mg in the form of amoxicillin trihydrate - 287 mg; clavulanic acid - 125 mg, in the form of potassium clavulanate - 149 mg.

Excipients: microcrystalline cellulose - 231 mg, sodium carboxymethyl starch - 24 mg, magnesium stearate - 5 mg.

Film coating: hypromellose - 28.2 mg. macrogol-4000 - 0.9 mg, titanium dioxide - 0.9 mg.

Dosage 500 + 125 mg

Active ingredients: amoxicillin - 500 mg in the form of amoxicillin trihydrate - 574 mg; clavulanic acid - 125 mg as potassium clavulanate - 149 mg.

Excipients: microcrystalline cellulose - 248 mg, sodium carboxymethyl starch - 86 mg, magnesium stearate - 42 mg.

Film coating: hypromellose - 41.36 mg, macrogol-4000 - 1.32 mg, titanium dioxide - 1.32 mg.

Active ingredients: amoxicillin - 875.0 mg, in the form of amoxicillin trihydrate - 1004.5 mg; clavulanic acid - 125 mg, in the form of potassium clavulanate - 149 mg.

Excipients: microcrystalline cellulose - 250 mg, sodium carboxymethyl starch - 180 mg, magnesium stearate - 90 mg.

Film coating: hypromellose - 70.50 mg, macrogol-4000 - 2.25 mg, titanium dioxide - 2.25 mg.

Causes of occurrence:

The causative agents of lower respiratory tract infections can be various gram-positive, gram-negative, atypical and anaerobic microorganisms. One of the most common respiratory pathogens to date remains pneumococcus (S. http://m.wisegeek.com/what-are-the-signs-of-an-allergic-reaction-to-amoxicillin.htm pneumoniae). Haemophilus influenzae (H. influenzae) is also considered one of the most common causative agents of respiratory infections, in particular community-acquired pneumonia and exacerbations of COPD..

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